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Article

RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance.

Cellular signalling - 1 Aug 2010

Hadj-Slimane Réda, Pamonsinlapatham Perayot, Herbeuval Jean-Philippe, Garbay Christiane, Lepelletier Yves, Raynaud Françoise

Abstract excerpt

Several cancers are treated by interferons alpha and gamma in association with conventional chemotherapy due to the resistance observed with interferon treatment alone. The frequency of un-sensitive cancer depends on tumor origin and oncogenic genes. Preclinical studies have highlighted interferon resistance in many cancers such as colon carcinoma due to oncogenic Ras. However, the resistance mechanism remains...

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PMID: 20362665
DOI: 10.1016/j.cellsig.2010.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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