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Article

Thymineless death in colon carcinoma cells is mediated via Fas signaling

22 Jul 1997

Abstract excerpt

Fas is expressed constitutively in colonic epithelial cells and is also expressed in colon carcinomas and in cultured colon carcinoma cell lines. However, the potential role of Fas signaling in mediating apoptosis in cells of this type remains unknown. We have developed human colon carcinoma cell models deficient in thymidylate synthase that demonstrate acute (TS- cells) or delayed (Thy4 cells) apoptosis...

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PMID: 9223329
DOI: 10.1073/pnas.94.15.8144

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Source receipt: pubmed, retrieved 7 Sept 2026.

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