Article
A novel mutant from apoptosis-resistant colon cancer HT-29 cells showing hyper-apoptotic response to hypoxia, low glucose and cisplatin.
Japanese journal of cancer research : Gann - 1 Nov 1998
Suzuki H, Tomida A, Tsuruo T
Abstract excerpt
Solid tumors usually have regions of hypoxia and glucose deprivation. Human colon carcinoma HT-29 cells show an apoptosis-resistant phenotype in response to microenvironmental stresses. In this study, we isolated a novel mutant of HT-29, designated as HA511, that showed a high apoptotic response...
Topics
- Antineoplastic Agents
- Apoptosis
- Cell Hypoxia
- Cisplatin
- Colonic Neoplasms
- Drug Screening Assays, Antitumor
- Endoplasmic Reticulum Chaperone BiP
- G1 Phase
- Glucose
- Humans
- Mutation
- Stimulation, Chemical
- Tumor Cells, Cultured