Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.

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Article

Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.

Oncogene - 16 May 1996

Harwood F G, Frazier M W, Krajewski S, Reed J C, Houghton J A

Abstract excerpt

The endogenous expression of p53 and p53-regulated genes has been examined in a thymidylate synthase-deficient colon carcinoma cell line (TS-) and a derived mutant clone (Thy4) that exhibit acute or delayed apoptotic responses, respectively, when released from G0 synchrony under conditions of dTh...

Topics

Alleles
Apoptosis
Base Sequence
Codon
Colonic Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, p53
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Nucleosomes

Point Mutation

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Thymidine

Source

Open in PubMed

Identifiers

PMID: 8668331

Genes

CAT
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8668331-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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