Article
Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac.
Cancer research - 15 Jan 1999
Mahmoud N N, Bilinski R T, Churchill M R, Edelmann W, Kucherlapati R, Bertagnolli M M
Abstract excerpt
The adenomatous polyposis coli (APC) gene product mediates coordinated cell growth in the intestinal mucosa. In humans, germ-line mutations of APC are associated with colorectal carcinogenesis, a process that varies in severity depending on the length of the protein resulting from the mutant alle...
Topics
- Adenomatous Polyposis Coli
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Cell Movement
- Cytoskeletal Proteins
- Female
- Genes, APC
- Genotype
- Intestinal Mucosa
- Intestines
- Mice
- Mutation
- Phenotype
- Precancerous Conditions
- Sulindac
- Trans-Activators
- beta Catenin