Article
Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac.
Cancer research - 15 Jan 1999
Mahmoud N N, Bilinski R T, Churchill M R, Edelmann W, Kucherlapati R, Bertagnolli M M
Abstract excerpt
The adenomatous polyposis coli (APC) gene product mediates coordinated cell growth in the intestinal mucosa. In humans, germ-line mutations of APC are associated with colorectal carcinogenesis, a process that varies in severity depending on the length of the protein resulting from the mutant allele. In a previous study of the C57BL/6J-Min/+ (Min/+) mouse, we found that the protein fragment resulting from...
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