Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1.

doi:10.1006/jmbi.1998.2473

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Article

Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1.

Journal of molecular biology - 5 Feb 1999

Najera I, Krieg M, Karn J

Abstract excerpt

The structural and accessory proteins of human immunodeficiency virus type 1 are expressed by unspliced or partially spliced mRNAs. Efficient transport of these mRNAs from the nucleus requires the binding of the viral nuclear transport protein Rev to an RNA stem-loop structure called the RRE (Rev...

Topics

Base Sequence
Binding Sites
Cell Nucleus
Cytoplasm
Gene Expression Regulation, Viral
Gene Products, gag
Gene Products, rev
Globins
HIV Antigens
HIV-1
Heterogeneous Nuclear Ribonucleoprotein A1
Heterogeneous-Nuclear Ribonucleoprotein Group A-B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterogeneous-Nuclear Ribonucleoprotein Group C

Heterogeneous-Nuclear Ribonucleoproteins

Humans

Molecular Sequence Data

Mutation

Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 9925777
DOI: 10.1006/jmbi.1998.2473

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9925777-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1.PMID 9925777Read ↗

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hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expressionSemantic proximity Read ↗

Role of Viral Splicing Elements and Cellular RNA Binding Proteins in Regulation of HIV-1 Alternative RNA SplicingSemantic proximity Read ↗

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein.Semantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

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Effect of Rev on the intranuclear localization of HIV-1 unspliced RNA.Semantic proximity Read ↗

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HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression.Semantic proximity Read ↗

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.Semantic proximity Read ↗

An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization.Semantic proximity Read ↗

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