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Article

Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.

Journal of molecular biology - 29 Mar 1996

Mikaélian I, Krieg M, Gait M J, Karn J

Abstract excerpt

The human immunodeficiency virus type (HIV-1) Rev protein stimulates the export to the cytoplasm of unspliced HIV-1 mRNAs carrying the Rev response element (RRE). However, simple addition of the RRE to beta-globin pre-mRNA does not confer a Rev response on this heterologous transcript. In this paper, we demonstrate that a strong Rev response is conferred on beta-globin pre-mRNA when an inhibitory (INS) element is...

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Source

Identifiers

PMID: 8609621
DOI: 10.1006/jmbi.1996.0160

Genes

INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.PMID 8609621Read ↗

Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1.Semantic proximity Read ↗

Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formationSemantic proximity Read ↗

Role of Viral Splicing Elements and Cellular RNA Binding Proteins in Regulation of HIV-1 Alternative RNA SplicingSemantic proximity Read ↗

Effect of Rev on the intranuclear localization of HIV-1 unspliced RNA.Semantic proximity Read ↗

Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.Semantic proximity Read ↗

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein.Semantic proximity Read ↗

Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expressionSemantic proximity Read ↗

Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.Semantic proximity Read ↗

Identification and characterization of intragenic sequences which repress human immunodeficiency virus structural gene expressionSemantic proximity Read ↗

Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.Semantic proximity Read ↗

Role of the Hepatitis B Virus Posttranscriptional Regulatory Element in Export of Intronless TranscriptsSemantic proximity Read ↗

The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA.Semantic proximity Read ↗

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