Article
Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAs.
Journal of molecular biology - 29 Mar 1996
Mikaélian I, Krieg M, Gait M J, Karn J
Abstract excerpt
The human immunodeficiency virus type (HIV-1) Rev protein stimulates the export to the cytoplasm of unspliced HIV-1 mRNAs carrying the Rev response element (RRE). However, simple addition of the RRE to beta-globin pre-mRNA does not confer a Rev response on this heterologous transcript. In this pa...
Topics
- Animals
- Base Sequence
- Cell Nucleus
- Cytoplasm
- Gene Expression
- Gene Products, gag
- Gene Products, rev
- Genes, Reporter
- Genes, gag
- Genes, pol
- Genetic Complementation Test
- Globins
- Granulocyte-Macrophage Colony-Stimulating Factor
- HIV Antigens
- HIV-1
- HeLa Cells
- Humans
- Models, Genetic