Article
Genotypic and phenotypic characterization of six new recombinant congenic strains derived from NOD/Shi and CBA/J genomes.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 1999
Reifsnyder P C, Flynn J C, Gavin A L, Simone E A, Sharp J J, Herberg L, Leiter E H
Abstract excerpt
Recombinant Congenic Strains (RCS) are useful for dissecting complex polygenic traits. Here, we describe genetic and phenotypic characterization of six new RCS generated from outcrosses between NOD/Shi and CBA/LsLt, followed by sib mating of first backcross progeny (to CBA) for 20 generations, wh...
Topics
- Animals
- Chromosomes
- Diabetes Mellitus, Type 1
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genome
- Genotype
- Leukocytes
- Male
- Mice
- Mice, Congenic
- Mice, Inbred CBA
- Mice, Inbred NOD
- Phenotype
- Recombination, Genetic
- Spleen