Article
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.
Genomics - 15 May 2001
Fortin A, Diez E, Rochefort D, Laroche L, Malo D, Rouleau G A, Gros P, Skamene E
Abstract excerpt
Complex genetic traits can be dissected in mice, using well-defined sets of recombinant inbred strains, congenic strains, and recombinant congenic strains (RCS). We report the creation of a series of 37 independent RCS derived from the commonly used inbred strains of laboratory mouse A/J (A) and C57BL/6J (B6). These RCS were derived by systematic inbreeding of independent pairs of animals from a (F1 x A) x A and...
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