Article
Molecular and immunohistochemical study of the inactivation of the p16 gene in primary hepatocellular carcinoma.
Chinese medical journal - 1 Oct 2000
Huang J, Shen W, Li B, Luo Y, Liao S, Zhang W, Cheng N
Abstract excerpt
OBJECTIVE: To determine whether p16 gene is involved in the genesis of primary hepatocellular carcinoma (HCC). METHODS: Twenty-five HCC tumor samples with corresponding non-tumor liver tissue specimens were examined for p16 gene alterations. The identification of deletion of exon 1 and exon 2 in p16 gene was performed using comparative multiplex polymerase chain reaction (PCR) analysis. The point mutation of exon...
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