Article
p16INK4A gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy.
Journal of gastroenterology and hepatology - 1 Apr 2004
Anzola Monica, Cuevas Nerea, Lopez-Martinez Monica, Martinez de Pancorbo Marian, Burgos Juan Jose
Abstract excerpt
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a common malignancy worldwide that is highly associated with chronic hepatitis B or C infection and cirrhosis. The tumor suppressor gene p16INK4A is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. The present study was performed to determine genetic and epigenetic alterations in the p16INK4A...
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