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Article

Inactivation of P16Ink4 in Hepatocellular Carcinoma

1 Sept 1996

Abstract excerpt

We analyzed the p16INK4 status of 6 hepatocellular carcinoma (HCC) cell lines and 32 primary HCC tumors, including 9 early-stage tumors, to determine whether p16INK4 tumor-suppressor gene inactivation participates in hepatocarcinogenesis. p16INK4 was studied at its protein level through Western blotting, at its messenger RNA (mRNA) level through reverse-transcriptase polymerase chain reaction analysis (RT-PCR)...

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Identifiers

PMID: 8781327
DOI: 10.1002/hep.510240319

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