Article
Lectin-induced inhibition of desensitization of the kainate receptor GluR6 depends on the activation state and can be mediated by a single native or ectopic N-linked carbohydrate side chain.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1999
Everts I, Petroski R, Kizelsztein P, Teichberg V I, Heinemann S F, Hollmann M
Abstract excerpt
The ionotropic glutamate receptor GluR6 exhibits strongly and rapidly desensitizing current responses. Treatment of heterologically expressed GluR6 with the lectin concanavalin A (ConA) in Xenopus oocytes as well as in human embryonic kidney-293 cells results in a considerable increase of the ste...
Topics
- Animals
- Carbohydrates
- Cell Line
- Concanavalin A
- Dose-Response Relationship, Drug
- Glycosylation
- Humans
- Mutation
- Oocytes
- Receptors, Kainic Acid
- Time Factors
- Xenopus laevis