Article
Two genetically selected strains of rats exhibit hypersensitivity or resistance to cocaine-induced fatal arrhythmias.
The Journal of pharmacology and experimental therapeutics - 1 Feb 1999
Shi B, Heavner J E, Liu J, Wang M J, Lutherer L O, McIntyre D C, Reigel C E
Abstract excerpt
We identified for the first time two genetically selected strains of rats that differ markedly in sensitivity to cocaine-induced life-threatening cardiac arrhythmias and arrest. The two strains of rats, designated as Fast and Slow, were bred for sensitivity (Fast) or resistance (Slow) to electric...
Topics
- Animals
- Arrhythmias, Cardiac
- Autonomic Nervous System
- Cocaine
- Dose-Response Relationship, Drug
- Drug Hypersensitivity
- Drug Tolerance
- Electrocardiography
- Female
- Genetic Predisposition to Disease
- Heart Arrest
- Hemodynamics
- Male
- Myocardium
- Rats
- Rats, Wistar
- Receptors, Adrenergic, alpha
- Sensitivity and Specificity