Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Nov 2000

Shi B, Heavner J E, Reigel C E, Kao Y J, Kaye A D

Abstract excerpt

The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs). Moderate seizure (GEPR-3) and severe seizure (GEPR-9) rats, and the control strain, Sprague-Dawley rats, 10 weeks of age, were lightly anesthetized with halothane and nitrous oxide. Following surgical preparation and stabilization, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arrhythmias, Cardiac
Share to Cocaine
Share to Electroencephalography

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epilepsy

Share to gamma-Aminobutyric Acid

Share to Rats, Sprague-Dawley

Share to Seizures

Source

Identifiers

PMID: 11111834
DOI: 10.1007/s002100000297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.PMID 11111834Read ↗

Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.Semantic proximity Read ↗

Alterations in neuronal gamma-aminobutyric acid(A) receptor responsiveness in genetic models of seizure susceptibility with different expression patterns.Semantic proximity Read ↗

Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.Semantic proximity Read ↗

Two genetically selected strains of rats exhibit hypersensitivity or resistance to cocaine-induced fatal arrhythmias.Semantic proximity Read ↗

Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment.Semantic proximity Read ↗

Pharmacogenetic assessment of the effects of carbamazepine on cocaine-kindled and cocaine-induced seizures.Semantic proximity Read ↗

Sleep, temperature, activity, and prolactin phenotypes of genetically epilepsy-prone rats.Semantic proximity Read ↗

Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats.Semantic proximity Read ↗

Marked strain and substrain differences in induction of status epilepticus and subsequent development of neurodegeneration, epilepsy, and behavioral alterations in rats. [corrected].Semantic proximity Read ↗

Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains.Semantic proximity Read ↗

Cocaine cardiotoxicity differs markedly in isolated hearts of two strains of rats exhibiting phenotypic differences in sensitivity to seizures.Semantic proximity Read ↗

Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.