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Article

Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment.

Brain research - 22 Feb 1991

Marley R J, Witkin J M, Goldberg S R

Abstract excerpt

Repeated administration of doses of cocaine below the threshold for seizure induction results in the development of an increased susceptibility to cocaine-induced seizures (cocaine-kindling). Genetic differences in susceptibility to cocaine-kindled seizures were evaluated in 4 inbred mouse strains and compared with susceptibility to seizures induced by acute administration of cocaine. The acute administration of...

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Identifiers

PMID: 2054648
DOI: 10.1016/0006-8993(91)90989-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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