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Article

Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment.

Brain research - 22 Feb 1991

Marley R J, Witkin J M, Goldberg S R

Abstract excerpt

Repeated administration of doses of cocaine below the threshold for seizure induction results in the development of an increased susceptibility to cocaine-induced seizures (cocaine-kindling). Genetic differences in susceptibility to cocaine-kindled seizures were evaluated in 4 inbred mouse strains and compared with susceptibility to seizures induced by acute administration of cocaine. The acute administration of...

Topics

Animals
Cocaine
Drug Resistance
Genetic Predisposition to Disease
Kindling, Neurologic
Male
Mice
Mice, Inbred Strains
Seizures
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2054648
DOI: 10.1016/0006-8993(91)90989-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2054648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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