Cocaine cardiotoxicity differs markedly in isolated hearts of two strains of rats exhibiting phenotypic differences in sensitivity to seizures.

doi:10.1016/s0024-3205(98)00314-2

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Article

Cocaine cardiotoxicity differs markedly in isolated hearts of two strains of rats exhibiting phenotypic differences in sensitivity to seizures.

Life sciences - 1 Jan 1998

Heavner J E, Shi B, Inners-McBride K, Asimakis G, Wang M J, McIntyre D C

Abstract excerpt

Isolated hearts from two strains of rats bred for sensitivity or resistance to amygdala kindling that also exhibit, in vivo, differential sensitivity to the cardiotoxicity of cocaine were studied. The goal was to determine if the differential cardiotoxic sensitivity was due, at least in part, to...

Topics

Amygdala
Animals
Blood Pressure
Cocaine
Coronary Vessels
Diastole
Electrocardiography
Heart Diseases
Heart Rate
Kindling, Neurologic
Male
Phenotype
Rats
Seizures
Time Factors
Ventricular Function, Left

Source

Open in PubMed

Identifiers

PMID: 9718092
DOI: 10.1016/s0024-3205(98)00314-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9718092-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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