Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetic assessment of the effects of carbamazepine on cocaine-kindled and cocaine-induced seizures.

Brain research - 1 May 1992

Marley R J, Goldberg S R

Abstract excerpt

The effects of chronic carbamazepine (CBZ) on the development and expression of cocaine-kindled seizures and seizures produced by an acute injection of cocaine were evaluated in BALB/cByJ, C57Bl/6J and SJL/J mice. The repeated administration of a subconvulsant dose of cocaine initially resulted in the development of an increased sensitivity to the convulsant effects of cocaine in the three strains. Chronic,...

Topics

Animals
Anticonvulsants
Carbamazepine
Cocaine
Genotype
Kindling, Neurologic
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred Strains
Seizures

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1623406
DOI: 10.1016/0006-8993(92)90739-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1623406-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetic assessment of the effects of carbamazepine on cocaine-kindled and cocaine-induced seizures.PMID 1623406Read ↗

Genetic factors influence changes in sensitivity to the convulsant properties of cocaine following chronic treatment.Semantic proximity Read ↗

Differential cocaine sensitivity between two closely related substrains of C57BL mice.Semantic proximity Read ↗

Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.Semantic proximity Read ↗

Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.Semantic proximity Read ↗

Sensitization to stereotypy in DBA/2J but not C57BL/6J mice with repeated cocaine.Semantic proximity Read ↗

Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains.Semantic proximity Read ↗

Pharmacokinetic and pharmacodynamic analyses of cocaine and its metabolites in behaviorally divergent inbred mouse strains.Semantic proximity Read ↗

Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype.Semantic proximity Read ↗

Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice.Semantic proximity Read ↗

Increased acute cocaine sensitivity and decreased cocaine sensitization in GABA(A) receptor beta3 subunit knockout mice.Semantic proximity Read ↗

Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.Semantic proximity Read ↗

Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.