Article
Thrombospondins I and II messenger RNA expression in lung carcinoma: relationship with p53 alterations, angiogenic growth factors, and vascular density.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 1999
Fontanini G, Boldrini L, Calcinai A, Chinè S, Lucchi M, Mussi A, Angeletti C A, Basolo F, Bevilacqua G
Abstract excerpt
Thrombospondin (TSP) is a Mr 450,000 multifunctional matrix glycoprotein that interferes with tumor growth, angiogenesis, and metastasis. It has recently been shown that TSP expression is enhanced by the product of the p53 gene and that a down-regulation of TSP may be observed when alterations of the p53 protein occur. Moreover, a number of studies have demonstrated a regulatory activity of p53 on human vascular...
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