Article
Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice.
The American journal of pathology - 1 Nov 2001
Lawler J, Miao W M, Duquette M, Bouck N, Bronson R T, Hynes R O
Abstract excerpt
In vitro and in vivo data indicate that thrombospondin-1 (TSP1) inhibits tumor progression in several ways including direct effects on cellular growth and apoptosis in the stromal compartment. To evaluate the importance of TSP1 for the progression of naturally arising tumors in vivo, we have cros...
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