Article
Correlation of intratumoral microvessel density and p53 protein overexpression in human colorectal adenocarcinoma.
Microvascular research - 1 Mar 1996
Vermeulen P B, Roland L, Mertens V, Van Marck E, De Bruijn E A, Van Oosterom A T, Dirix L Y
Abstract excerpt
A malignant cell population needs the development of microvessels in order to grow and metastasize. Recently, a role for the p53 gene in the regulation of this angiogenic process has been suggested. Wild-type p53 is involved in the secretion of Trombospondin-1 (TSP-1), an angiogenesis inhibitor. Mutations of the p53 gene cause a downregulation of TSP-1 mRNA in cell lines. Mutant p53 also upregulates the...
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