Article
Correlation of intratumoral microvessel density and p53 protein overexpression in human colorectal adenocarcinoma.
Microvascular research - 1 Mar 1996
Vermeulen P B, Roland L, Mertens V, Van Marck E, De Bruijn E A, Van Oosterom A T, Dirix L Y
Abstract excerpt
A malignant cell population needs the development of microvessels in order to grow and metastasize. Recently, a role for the p53 gene in the regulation of this angiogenic process has been suggested. Wild-type p53 is involved in the secretion of Trombospondin-1 (TSP-1), an angiogenesis inhibitor....
Topics
- Adenocarcinoma
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- Female
- Gene Expression
- Humans
- Immunohistochemistry
- Male
- Microcirculation
- Middle Aged
- Mutation
- Neovascularization, Pathologic
- Prognosis
- Tumor Suppressor Protein p53