Article
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2008
Regina Sandra, Rollin Jérôme, Bléchet Claire, Iochmann Sophie, Reverdiau Pascale, Gruel Yves
Abstract excerpt
INTRODUCTION: Tissue factor (TF) is the physiological trigger of blood coagulation, but it could also have an important role in cancer by regulating VEGF expression and angiogenesis. METHODS: TF expression was studied by real-time PCR in lung tumors of 64 patients with non-small-cell lung cancer (NSCLC) and by immunohistochemical analysis. The gene expression of two VEGF isoforms, VEGF165 and VEGF189, was also...
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