Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.

doi:10.1126/science.7521539

Back to search

Article

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.

Science (New York, N.Y.) - 9 Sept 1994

Dameron K M, Volpert O V, Tainsky M A, Bouck N

Abstract excerpt

As normal cells progress toward malignancy, they must switch to an angiogenic phenotype to attract the nourishing vasculature that they depend on for their growth. In cultured fibroblasts from Li-Fraumeni patients, this switch was found to coincide with loss of the wild-type allele of the p53 tum...

Topics

Alleles
Cells, Cultured
Fibroblasts
Gene Expression Regulation
Genes, p53
Humans
Li-Fraumeni Syndrome
Membrane Glycoproteins
Neovascularization, Pathologic
Phenotype
Promoter Regions, Genetic
Thrombospondins
Transfection

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.