Article
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.
Science (New York, N.Y.) - 9 Sept 1994
Dameron K M, Volpert O V, Tainsky M A, Bouck N
Abstract excerpt
As normal cells progress toward malignancy, they must switch to an angiogenic phenotype to attract the nourishing vasculature that they depend on for their growth. In cultured fibroblasts from Li-Fraumeni patients, this switch was found to coincide with loss of the wild-type allele of the p53 tumor suppressor gene and to be the result of reduced expression of thrombospondin-1 (TSP-1), a potent inhibitor of...
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