Article
p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer.
Pharmacogenetics - 1 Dec 1998
Przygodzki R M, Bennett W P, Guinee D G, Khan M A, Freedman A, Shields P G, Travis W D, Jett J R, Tazelaar H, Pairolero P, Trastek V, Liotta L A, Harris C C, Caporaso N E
Abstract excerpt
p53 mutation status was analysed in relation to DNA polymorphisms of GSTM1, CYP1A1 and CYP2E1 from 105 surgically resected non-small cell lung cancer cases. Demographic factors, smoking, occupation, family history, tumour histology, grade and stage were taken into account. p53 mutations, detected...
Topics
- Carcinoma, Non-Small-Cell Lung
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2E1
- Disease-Free Survival
- Genes, p53
- Glutathione Transferase
- Heterozygote
- Homozygote
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Mutation