p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.

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Article

p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.

Cancer research - 15 Mar 1994

Ryberg D, Kure E, Lystad S, Skaug V, Stangeland L, Mercy I, Børresen A L, Haugen A

Abstract excerpt

We have screened 108 non-small cell lung tumors for mutational alterations in the p53 gene (exons 5 through 8) using polymerase chain reaction and denaturing gel electrophoresis techniques. Thirty-four cases (32%) had aberrant band migrations. The following DNA-sequencing step confirmed the mutat...

Topics

Alleles
Base Sequence
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Chromosomes, Human, Pair 17
DNA, Neoplasm
Exons
Genes, p53
Genes, ras
Genetic Markers
Genetic Variation
Genotype
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Smoking

Source

Open in PubMed

Identifiers

PMID: 8137262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8137262-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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