Article
Effect of CYP1A1 MSPI polymorphism on the relationship between TP53 mutation and CDKN2A hypermethylation in non-small cell lung cancer.
Archives of medical research - 1 Nov 2011
Tan Cong, Xu He-Yun, Zhang Chen-Ye, Zhang Hu, Chen Chun-Mei, Zhang Wei-Min, Sun Xiao-Yu, Jin Yong-Tang
Abstract excerpt
BACKGROUND AND AIMS: The molecular mechanisms of lung cancer susceptibility have not been fully understood. Although it has been described that germline polymorphisms are associated with either mutation or methylation of genes, the link between gene polymorphisms and gene-gene interactions has not been investigated. Therefore, we conducted this study to determine whether CYP1A1/GSTM1 polymorphisms can affect the...
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