Article
Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation.
Anticancer research - 1 Jan 2000
Oyama T, Kawamoto T, Mizoue T, Sugio K, Kodama Y, Mitsudomi T, Yasumoto K
Abstract excerpt
The distribution of cytochrome P450 2E1 (CYP2E1) genetic polymorphism was compared in 126 patients with non-small cell lung cancer (NSCLC) and 612 control subjects by PCR-based assay. Incidence of C type (c2/c2) of CYP2E1 polymorphism in the patients with squamous cell carcinoma (9.4%) was significantly higher than that in healthy controls (4.1%) or in the patients with adenocarcinoma (2.7%) within the Japanese...
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