Article
Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland.
British journal of cancer - 1 Jul 1999
Rusin M, Butkiewicz D, Malusecka E, Zborek A, Harasim J, Czyzewski K, Bennett W P, Shields P G, Weston A, Welsh J A, Krzyzowska-Gruca S, Chorazy M, Harris C C
Abstract excerpt
The p53 mutation spectrum can generate hypotheses linking carcinogen exposure to human cancer. Although it is well-documented that tobacco smoking is a major cause of lung cancer, the contribution of air pollution is less well-established. We determined the molecular and immunohistochemical changes (p53 gene mutations, p53 protein accumulation and WAF1 protein expression) and genetic polymorphisms of GSTM1,...
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