Article
Molecular epidemiology of human cancer risk. Gene-environment interactions and p53 mutation spectrum in human lung cancer.
Methods in molecular medicine - 1 Jan 2003
Vähäkangas Kirsi
Abstract excerpt
Molecular epidemiology of cancer risk utilizes knowledge of both the genetic changes in cancer and the current hypothesis of chemical carcinogenesis when selecting possible markers for individual susceptibility, early disease, and biologically significant exposure. Polymorphisms of drug-metabolizing enzymes, especially CYP enzymes, and mutations in the p53 tumor-suppressor gene have been in the center of interest...
Topics
- Biomarkers, Tumor
- Environment
- Genes, Neoplasm
- Humans
- Lung Neoplasms
- Molecular Epidemiology
- Mutation
- Risk Factors
- Tumor Suppressor Protein p53