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Article

NF-Y binding to twin CCAAT boxes: role of Q-rich domains and histone fold helices.

Journal of molecular biology - 29 Jan 1999

Liberati C, di Silvio A, Ottolenghi S, Mantovani R

Abstract excerpt

NF-Y (CBF) is a CCAAT-binding trimer that activates 25 % of eukaryotic promoters. It contains putative histone fold motifs (HFMs) and distorts DNA. By using electrophoretic mobility shift assays with the twin CCAAT boxes of the human gamma-globin promoter and several combinations of subunit mutants, we dissected some of the structural features of CCAAT-box binding. NF-YA and NF-YC Q-rich domains significantly...

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PMID: 9917388
DOI: 10.1006/jmbi.1998.2384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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