Article

Structural bases for Nuclear Factor 1-X activation and DNA recognition. Prototypic insight into the NFI transcription factor family

2025-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Nuclear Factor I (NFI) proteins were first identified in adenovirus DNA replication and later as regulators of gene transcription, stem cell proliferation, and differentiation. They play key roles in development, cancer and congenital disorders. Within the NFI family, NFI-X is critical for neural stem cell biology, hematopoiesis, muscle development, muscular dystrophies and oncogenesis. Here, we...

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Literature Corpus work: b6e5e1a0-a66d-5d46-8143-02a179b3a9e6
DOI: 10.1101/2025.03.21.644642

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