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Article

Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.

Journal of molecular biology - 22 Sept 2000

Caretti G, Cocchiarella F, Sidoli C, Villard J, Peretti M, Reith W, Mantovani R

Abstract excerpt

Transcription of major histocompatibility complex (MHC) class II genes depends upon the trimeric complexes RFX and NF-Y binding to the conserved X-Y promoter elements. We produced and purified the RFX subunits from Escherichia coli, reconstituted DNA-binding to the mouse Ea X box and dissected the interactions with NF-Y. RFX and NF-Y do not interact in solution, but make cooperative interactions in EMSA: a...

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Source

Identifiers

PMID: 10986117
DOI: 10.1006/jmbi.2000.4028

Genes

CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.PMID 10986117Read ↗

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.Semantic proximity Read ↗

The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.Semantic proximity Read ↗

Dissection of the NF-Y transcriptional activation potential.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

NF-Y binding to twin CCAAT boxes: role of Q-rich domains and histone fold helices.Semantic proximity Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes.Semantic proximity Read ↗

NF-Y and the transcriptional activation of CCAAT promoters.Semantic proximity Read ↗

Class II MHC transcriptional mutants are defective in higher order complex formation.Semantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

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