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Article

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Reith W, Siegrist C A, Durand B, Barras E, Mach B

Abstract excerpt

Transcription of major histocompatibility complex (MHC) class II genes is controlled largely by the conserved promoter elements called the X and Y boxes. We show here that RFX, the X box-binding protein deficient in certain MHC class II-deficient immunodeficiency patients (CID), and the Y box-binding protein NF-Y bind cooperatively. Functional relevance of this protein-protein interaction is suggested by the fact...

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Identifiers

PMID: 8290561
DOI: 10.1073/pnas.91.2.554
PMCID: PMC42987

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Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.PMID 8290561Read ↗

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The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.Semantic proximity Read ↗

NF-Y binding to twin CCAAT boxes: role of Q-rich domains and histone fold helices.Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

NF-Y and the transcriptional activation of CCAAT promoters.Semantic proximity Read ↗

Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.Semantic proximity Read ↗

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CCAAT-binding factor NF-Y and RFX are required for in vivo assembly of a nucleoprotein complex that spans 250 base pairs: the invariant chain promoter as a model.Semantic proximity Read ↗

New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.Semantic proximity Read ↗

The X1 box of HLA-G promoter is a target site for RFX and Sp1 factors.Semantic proximity Read ↗

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