Article
Indication of linkage of serum IgE levels to the interleukin-4 gene and exclusion of the contribution of the (-590 C to T) interleukin-4 promoter polymorphism to IgE variation.
Genetic epidemiology - 1 Jan 1999
Dizier M H, Sandford A, Walley A, Philippi A, Cookson W, Demenais F
Abstract excerpt
Previous segregation analysis of a sample of 234 randomly selected Australian families showed evidence for a recessive major gene controlling serum immunoglobulin E (IgE) levels independently of the specific response to allergens (SRA). Since linkage has been recently reported between serum IgE l...
Topics
- Adolescent
- Adult
- Allergens
- Australia
- Child
- Chromosomes, Human, Pair 5
- Enzyme-Linked Immunosorbent Assay
- Female
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Genotype
- Humans
- Hypersensitivity, Immediate
- Immunoglobulin E