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Article

Major genes regulating total serum immunoglobulin E levels in families with asthma.

American journal of human genetics - 1 Nov 2000

Xu J, Postma D S, Howard T D, Koppelman G H, Zheng S L, Stine O C, Bleecker E R, Meyers D A

Abstract excerpt

Immunoglobulin E (IgE) has a major role in the pathogenesis of allergic disorders and asthma. Previous data from 92 families, each identified through a proband with asthma, showed evidence for two major genes regulating total serum IgE levels. One of these genes mapped to 5q31-33. In the current study, the segregation analysis was extended by the addition of 108 probands and their families, ascertained in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11023809
DOI: 10.1086/321190
PMCID: PMC1288559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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