Article
Lack of linkage between chromosome 5q23-33 markers and IgE/bronchial hyperreactivity in 67 Scottish families.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2000
Mansur A H, Christie G, Turner A, Bishop D T, Markham A F, Helms P, Morrison J F
Abstract excerpt
BACKGROUND: Raised serum immunoglobulin E (IgE) and bronchial hyperreactivity (BHR) are risk factors for the expression of the asthma phenotype. Previous studies have reported evidence for linkage between these traits and markers on the 5q23-33 cytokine gene cluster. OBJECTIVE: To test for linkage between total serum IgE/BHR and microsatellite markers which map to the 5q23-33 region in an ethnically distinct...
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