Article
Gating of cx46 gap junction hemichannels by calcium and voltage.
Pflugers Archiv : European journal of physiology - 1 Feb 1999
Pfahnl A, Dahl G
Abstract excerpt
Connexin 46 (cx46), when expressed in Xenopus oocytes, not only forms typical gap junction channels between paired cells but also forms open gap junction hemichannels in the plasma membrane of single cells. The gap junction hemichannels share properties with complete gap junction channels in terms of permeability and gating. Here we characterize the gate that closes hemichannels in response to increased calcium...
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