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Article

The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.

The Journal of membrane biology - 1 Feb 2015

Tong Jun-Jie, Minogue Peter J, Kobeszko Matthew, Beyer Eric C, Berthoud Viviana M, Ebihara Lisa

Abstract excerpt

An N-terminal mutant of connexin46 (T19M) alters a highly conserved threonine and has been linked to autosomal dominant cataracts. To study the cellular and functional consequences of substitution of this amino acid, T19M was expressed in Xenopus oocytes and in HeLa cells. Unlike wild-type Cx46, T19M did not induce intercellular conductances in Xenopus oocytes. In transfected HeLa cells, T19M was largely...

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Identifiers

PMID: 25404239
DOI: 10.1007/s00232-014-9752-y
PMCID: PMC4300453

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