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Article

Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.

American journal of physiology. Cell physiology - 1 May 2011

Tong Jun-Jie, Minogue Peter J, Guo Wenji, Chen Tung-Ling, Beyer Eric C, Berthoud Viviana M, Ebihara Lisa

Abstract excerpt

Gap junction channels, which are made of connexins, are critical for intercellular communication, a function that may be disrupted in a variety of diseases. We studied the consequences of two cataract-associated mutations at adjacent positions at the first extracellular boundary in human connexin50 (Cx50), W45S and G46V. Both of these mutants formed gap junctional plaques when they were expressed in HeLa cells,...

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Identifiers

PMID: 21228318
DOI: 10.1152/ajpcell.00384.2010
PMCID: PMC3093948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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