Article
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999
Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A, Sensel M, Reaman G H, Uckun F M
Abstract excerpt
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice that express only non-DNA binding dominant-negative "leukemogenic" Ikaros isoforms lacking critical N-terminal zinc fingers develop an aggressive form of lymphoblastic leukemia 3-6 months after birth. Therefore, we sought to determine whether molecular abnormalities involving the Ikaros...
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