Article
Cutting Edge: Predominant Expression of a Novel Ikaros Isoform in Normal Human Hemopoiesis
1 Aug 2001
Abstract excerpt
Murine studies implicate Ikaros proteins as regulators of hemopoiesis, particularly in the lymphoid lineages. High homology between murine and human Ikaros suggests that Ikaros expression in the two might be similar. However, initial human studies that focused on leukemia detected novel Ikaros transcripts in patient samples. Thus, novel Ikaros splice forms and DNA nonbinding isoforms were linked with malignancy....
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