Article
Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1999
Sun L, Crotty M L, Sensel M, Sather H, Navara C, Nachman J, Steinherz P G, Gaynon P S, Seibel N, Mao C, Vassilev A, Reaman G H, Uckun F M
Abstract excerpt
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development. Germ-line mutant mice that express only non-DNA binding dominant-negative "leukemogenic" Ikaros isoforms lacking critical NH2-terminal zinc fingers develop an aggressive form of T-cell leukemia. We studied Ikaros gene expression in leukemic cells from 18 children with T-cell acute lymphoblastic leukemia (T-ALL)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.