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Article

Role of Ikaros in T-cell acute lymphoblastic leukemia

1 Jan 2011

Abstract excerpt

Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia. Its role in T-cell leukemia, however, has been more...

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PMID: 21765975
DOI: 10.4331/wjbc.v2.i6.108

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