Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Aberrantly Spliced Oncogenic Ikaros Isoforms in Childhood Acute Lymphoblastic Leukemia

1 Dec 1999

Abstract excerpt

PURPOSE: We sought to determine if molecular abnormalities involving the Ikaros gene could contribute to the development of acute lymphoblastic leukemia (ALL) in children. PATIENTS AND METHODS: We studied Ikaros gene expression in normal human bone marrow, normal thymocytes, normal fetal liver-derived immature lymphocyte precursor cell lines, eight different ALL cell lines, and leukemic cells from 69 children...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Biochemical and Molecular Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10577847
DOI: 10.1200/jco.1999.17.12.3753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Aberrantly Spliced Oncogenic Ikaros Isoforms in Childhood Acute Lymphoblastic LeukemiaPMID 10577847Read ↗

Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.Semantic proximity Read ↗

Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Cutting Edge: Predominant Expression of a Novel Ikaros Isoform in Normal Human HemopoiesisSemantic proximity Read ↗

Ikaros and leukaemia.Semantic proximity Read ↗

Ikaros and Tumor Suppression in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALLSemantic proximity Read ↗

IKAROS Deletions Dictate a Unique Gene Expression Signature in Patients with Adult B-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

IKZF1 in acute lymphoblastic leukemia: the rise before the fall?Semantic proximity Read ↗

Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistanceSemantic proximity Read ↗

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.Semantic proximity Read ↗

Detection of different Ikaros isoforms in human leukaemias using real‐time quantitative polymerase chain reactionSemantic proximity Read ↗

Genetic inactivation of Ikaros is a rare event in human T-ALL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.