Article
Chicken ovalbumin upstream promoter-transcription factor, hepatocyte nuclear factor 3, and CCAAT/enhancer binding protein control the far-upstream enhancer of the rat alpha-fetoprotein gene.
DNA and cell biology - 1 Dec 1996
Thomassin H, Bois-Joyeux B, Delille R, Ikonomova R, Danan J L
Abstract excerpt
We have further characterized the most distal of the three alpha-fetoprotein (AFP) enhancers required for expression of the AFP gene in fetal hepatocytes and yolk sac endodermal cells. Almost total rat AFP enhancer 3 (E3) activity is driven by a 160-bp fragment at -6 kb containing three target regions for nuclear proteins that cooperate to stimulate transcription from the AFP and the thymidine kinase promoters in...
Topics
- Animals
- CCAAT-Enhancer-Binding Proteins
- COUP Transcription Factor I
- Carcinoma, Hepatocellular
- Chickens
- DNA
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Hepatocyte Nuclear Factor 3-alpha