Article
Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins.
Hepatology (Baltimore, Md.) - 1 Mar 1999
Bahr M J, Vincent K J, Arthur M J, Fowler A V, Smart D E, Wright M C, Clark I M, Benyon R C, Iredale J P, Mann D A
Abstract excerpt
In the injured liver hepatic stellate cells (HSCs) undergo a dramatic phenotypic transformation known as "activation" in which they become myofibroblast-like and express high levels of the tissue inhibitor of metalloproteinase 1 (TIMP-1). HSC activation is accompanied by transactivation of the TIMP-1 promoter. Truncation mutagenesis studies delineated a minimal active promoter consisting of nucleotides -102 to...
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