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Nuclear Receptor Hepatocyte Nuclear Factor 4α1 Competes with Oncoprotein c-Myc for Control of the p21/WAF1 Promoter

20 Sept 2007

Abstract excerpt

The dichotomy between cellular differentiation and proliferation is a fundamental aspect of both normal development and tumor progression; however, the molecular basis of this opposition is not well understood. To address this issue, we investigated the mechanism by which the nuclear receptor hepatocyte nuclear factor 4alpha1 (HNF4alpha1) regulates the expression of the human cyclin-dependent kinase inhibitor...

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Identifiers

PMID: 17885207
DOI: 10.1210/me.2007-0298

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