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Article

Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts.

Molecular and cellular biology - 1 Feb 1999

Duncker B P, Pasero P, Braguglia D, Heun P, Weinreich M, Gasser S M

Abstract excerpt

Nuclear extracts from Saccharomyces cerevisiae cells synchronized in S phase support the semiconservative replication of supercoiled plasmids in vitro. We examined the dependence of this reaction on the prereplicative complex that assembles at yeast origins and on S-phase kinases that trigger initiation in vivo. We found that replication in nuclear extracts initiates independently of the origin recognition...

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Identifiers

PMID: 9891057
DOI: 10.1128/MCB.19.2.1226
PMCID: PMC116052

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