Article
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.
The EMBO journal - 3 Feb 2003
Ragimbeau Josiane, Dondi Elisabetta, Alcover Andrés, Eid Pierre, Uzé Gilles, Pellegrini Sandra
Abstract excerpt
The four mammalian Jak tyrosine kinases are non-covalently associated with cell surface receptors binding helical bundled cytokines. In the type I interferon receptor, Tyk2 associates with the IFNAR1 receptor subunit and positively influences ligand binding to the receptor complex. Here, we report that Tyk2 is essential for stable cell surface expression of IFNAR1. In the absence of Tyk2, mature IFNAR1 is weakly...
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