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Article

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

Nature - 11 Nov 1993

Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur A G, Barbieri G, Witthuhn B A, Schindler C

Abstract excerpt

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1...

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Source

Identifiers

PMID: 8232552
DOI: 10.1038/366129a0

Genes

JAK1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.PMID 8232552Read ↗

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JAKS AND STATS: Biological ImplicationsSemantic proximity Read ↗

Janus kinases in immune cell signalingSemantic proximity Read ↗

Responses to Cytokines and Interferons that Depend upon JAKs and STATs.Semantic proximity Read ↗

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.Semantic proximity Read ↗

JAKs, STATs and signal transduction in response to the interferons and other cytokinesSemantic proximity Read ↗

Shared receptor components but distinct complexes for alpha and beta interferons.Semantic proximity Read ↗

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunitySemantic proximity Read ↗

The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the NucleusSemantic proximity Read ↗

Biology and significance of the JAK/STAT signalling pathways.Semantic proximity Read ↗

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