Article
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.
Nature - 11 Nov 1993
Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur A G, Barbieri G, Witthuhn B A, Schindler C
Abstract excerpt
We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction path...
Topics
- Animals
- Cell Line
- DNA-Binding Proteins
- Genetic Complementation Test
- Humans
- Interferon-Stimulated Gene Factor 3
- Interferon-Stimulated Gene Factor 3, gamma Subunit
- Interferon-alpha
- Interferon-beta
- Interferon-gamma
- Janus Kinase 1
- Janus Kinase 2
- Mice
- Mutation